|
T11075 |
Donitriptan
|
|
5-HT Receptor
|
|
Donitriptan is a 5-HT receptor agonist with pKis of 9.4 and 9.3 for 5-HT1B and 5-HT1D, respectively. |
|
T37015 |
Iprindole
|
|
5-HT Receptor
|
|
Iprindole, a tricyclic indole antidepressant, is a dual weak inhibitor of noradrenaline and 5-HT uptake [1]. |
|
T10075 |
2-Methyl-5-HT
|
2-Methyl-5-hydroxytryptamine |
5-HT Receptor
|
|
|
|
T8666 |
Naratriptan
|
|
5-HT Receptor
|
|
Naratriptan is a selective agonist of 5-HT1 receptor and is is used for the treatment of migraine headaches. |
|
T8441 |
Lerisetron
|
|
5-HT Receptor
|
|
Lerisetron is an antagonist of serotonin type 3 (5-HT3) receptor, with antiemetic activity. |
|
T2599 |
Pirenperone
|
|
5-HT Receptor
|
|
Pirenperone is a putative 5-HT2 receptor antagonist with the central antiserotonergic and antidopaminergic action. |
|
T21629 |
Loxapine
|
|
Dopamine Receptor
,
5-HT Receptor
|
|
Loxapine is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent,used primarily in the treatment of schizophrenia. The drug is a member of the dibenzoxazepine class ... |
|
T19680 |
Zotepine
|
|
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
|
Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic, and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM, and 8 nM, respectively. Zotepine is a second... |
|
T5336 |
Zacopride hydrochloride
|
|
Potassium Channel
,
5-HT Receptor
|
|
Zacopride is a highly potent 5-HT3 receptor antagonist (Kd = 0.38 nM) and 5-HT4 receptor agonist (Ki = 373 nM). It also is a selective IK1 channel agonist. |
|
T16669 |
PRX-08066
|
|
5-HT Receptor
|
|
PRX-08066 is a selective 5-hydroxytryptamine receptor 2B (5-HT2BR, IC50= 3.4 nM) antagonist that induces selective vasodilation of pulmonary arteries. |
|
T6728 |
VUF 10166
|
|
5-HT Receptor
|
|
VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower. |
|
T22921 |
LE 300
|
|
Dopamine Receptor
,
5-HT Receptor
|
|
dopamine D1 receptor antagonist |
|
T22514 |
4F 4PP oxalate
|
|
5-HT Receptor
|
|
4F 4PP oxalate is a 5-HT2A antagonist. |
|
T10169 |
5-HT4 antagonist 1
|
|
5-HT Receptor
|
|
|
|
T12489 |
Pimethixene
|
Calmixen,Pimetixene |
Dopamine Receptor
,
5-HT Receptor
,
AChR
,
Histamine Receptor
|
|
Pimethixene (Calmixen) is a highly potent 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors antagonist(pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 ... |
|
T8946 |
Indophagolin
|
|
P2X Receptor
,
5-HT Receptor
,
Autophagy
|
|
Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. |
|
T0280 |
Spiperone
|
Spiroperidol,Spiropitan |
Dopamine Receptor
|
|
Spiperone (Spiropitan) is a spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA. |
|
TQ0311 |
GSK163090
|
|
Dopamine Receptor
,
5-HT Receptor
|
|
GSK163090 is a specific and orally active 5-HT1A/B/D receptor antagonist (pKis: 9.4/8.5/9.7, and 6.3/6.7 for 5-HT1A/B/D, and dopamine D2/D3). |
|
T21946 |
BIMU 8
|
|
5-HT Receptor
|
|
BIMU 8 is a selective agonist of 5-HT4 with EC50s of 18 nM, 77 nM, and 540 nM for wild-type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4. |
|
T17033 |
Temanogrel
|
APD791 |
5-HT Receptor
|
|
Temanogrel (APD791) is a highly selective antagonist of the 5-HT2A receptor (Ki: 4.9 nM). |
|
T12847 |
SB-616234-A
|
SB-616234A |
5-HT Receptor
|
|
SB-616234A is a selective and orally bioavailable antagonist of 5-HT1B receptor, with anxiolytic and antidepressant activity. |
|
T5387 |
LP-211
|
|
Dopamine Receptor
,
5-HT Receptor
|
|
LP-211 is a brain penetrant selective agonist for a 5-HT7 receptor (Ki: 0.58 nM), and >300-fold selectivity over the 5-HT1A receptor. |
|
T8357 |
SB-200646
|
|
5-HT Receptor
|
|
SB-200646 is a selective and potent antagonist of 5-HT2B/5-HT2C receptor |
|
T2344 |
LY 344864
|
LY344864 |
5-HT Receptor
|
|
LY 344864, a specifc receptor agonist, is an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor. |
|
T11720 |
JNJ-18038683
|
|
5-HT Receptor
|
|
JNJ-18038683 is a 5-Hydroxytryptamine Type 7 (5-HT7) receptor antagonist, with pKis of 8.19, 8.20 for rat and human 5-HT7 in HEK293 cells, respectively. |
|
T22987 |
MK 212 hydrochloride
|
|
5-HT Receptor
|
|
MK 212 hydrochloride is a 5-HT2C receptor agonist |
|
T4305 |
8-OH-Dpat
|
8-Hydroxy-DPAT |
5-HT Receptor
|
|
8-OH-Dpat (8-Hydroxy-DPAT) is a serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin. |
|
T9272 |
Xaliproden hydrochloride
|
|
Dopamine Receptor
,
5-HT Receptor
|
|
Xaliproden is a compound that mimics the effects of nerve growth factor and is also a serotonin 5-HT1A receptor agonist. |
|
T2428 |
TG6-10-1
|
|
5-HT Receptor
,
Prostaglandin Receptor
|
|
TG6-10-1 is an EP2 antagonist. |
|
T0165 |
Urapidil
|
Mediatensyl,Ebrantil,Eupressyl |
5-HT Receptor
,
Adrenergic Receptor
|
|
Urapidil (Ebrantil), a sympatholytic antihypertensive drug, acts as a 5-HT1A receptor agonist and as an α1-adrenoceptor antagonist. |
|
T12855 |
SB 258719
|
|
5-HT Receptor
|
|
|
|
T39161 |
Ro60-0175
|
Ro60-0175 |
5-HT Receptor
|
|
Ro60-0175 a selective agonist for both the 5-hydroxytryptamine 2B (5-HT2B) and 5-hydroxytryptamine 2C (5-HT2C)serotonin receptor subtypes, commonly used as fumarate salt. It has a role as a 5-hydroxytryptamine 2B recept... |
|
T2631 |
WAY-100635 Monomaleate
|
|
Dopamine Receptor
,
5-HT Receptor
|
|
WAY-100635 is a specific and effective 5-HT receptor antagonist (IC50=0.95 nM). |
|
T15270 |
Fananserin
|
RP 62203 |
Dopamine Receptor
,
5-HT Receptor
|
|
Fananserin is an orally bioavailable and selective antagonist of the 5-HT2 receptor (Ki: 0.37 nM for the rat 5-HT2A receptor). It also is an antagonist of dopamine D4 receptor (Ki: 2.93 nM for the human dopamine D4 recep... |
|
T13275 |
Vabicaserin hydrochloride
|
SCA 136 |
5-HT Receptor
|
|
Vabicaserin hydrochloride (SCA 136) is a selective agonist of 5-hydroxytryptamine 2C (5-HT2C) receptor (EC50: 8 nM). |
|
T0162 |
Quetiapine
|
ICI204636,Quetiapin |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
AChR
,
Histamine Receptor
|
|
Quetiapine (ICI204636) is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapine' action is thought by mediated through antago... |
|
T21337 |
Lurasidone
|
SM-13496 |
Dopamine Receptor
,
5-HT Receptor
|
|
Lurasidone (SM-13496) is an antagonist of both dopamine D2 and 5-HT7(IC50=1.68 and 0.495 nM, respectively).It also a partial agonist of 5-HT1A receptor(IC50 : 6.75 nM). |
|
T37197 |
5-HT1A modulator 2 hydrochloride
|
|
5-HT Receptor
|
|
5-HT1A modulator 2 hydrochloride, a derivative of 8-OH-DPAT , is a modulator of 5-HT1A with a Ki of 53 nM for 5-HT1A binding[1].
[1]. Naiman, N.,et al. 2-(Alkylamino)tetralin derivatives: interaction with 5-HT1A serotoni... |
|
T4568 |
Dolasetron
|
MDL-73147 |
5-HT Receptor
|
|
Dolasetron (MDL-73147)(MDL-73147) is a serotonin 5-HT3 receptor antagonist. Dolasetron is used to treat nausea and vomiting following chemotherapy. |
|
T4616 |
Metoclopramide
|
5-Chloro-2-methoxyprocainamide |
Dopamine Receptor
,
5-HT Receptor
|
|
Metoclopramide (5-Chloro-2-methoxyprocainamide) is a dopamine D2 antagonist which has been used for treatment of a variety of gastrointestinal symptoms over the last thirty years. In various countries, metoclopramide is ... |
|
T4348 |
Syk Inhibitor II
|
|
5-HT Receptor
,
Syk
|
|
Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = 41 nM). |
|
T11217 |
Eplivanserin
|
SR-46349 |
5-HT Receptor
|
|
|
|
T0088 |
Urapidil hydrochloride
|
Urapidil HCl |
5-HT Receptor
,
Adrenergic Receptor
|
|
Urapidil hydrochloride (Urapidil HCl) is 5-HT1A receptor agonist and an α1-adrenoceptor antagonist. |
|
T21011 |
Buspirone
|
Buspirone free base,Ansial |
5-HT Receptor
|
|
Buspirone (Buspirone free base) is an azaspiro compound which has a role as an anxiolytic drug, a sedative, a serotonergic agonist and an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor. |
|
T16421 |
P-MPPI hydrochloride
|
|
5-HT Receptor
|
|
p-MPPI hydrochloride is a selective antagonist of 5-HT1A receptor, and has antidepressant and anxiolytic-like effects. |
|
T12172 |
NAN-190 hydrobromide
|
|
5-HT Receptor
|
|
NAN-190 hydrobromide is an antagonist of serotonin receptor 5-HT. |
|
T3179 |
Eptapirone
|
F 11440 |
5-HT Receptor
|
|
Eptapirone (F 11440) is a highly effective and selective 5-HT1A receptor agonist with marked antidepressant and anxiolytic potential. |
|
T22671 |
CJ 033466
|
|
5-HT Receptor
|
|
CJ 033466 is a selective partial agonist of 5-HT4 receptor (EC50 = 9 nM) with gastroprokinetic effect. |
|
T0137 |
Mirtazapine
|
6-Azamianserin,Org3770 |
Dopamine Receptor
,
5-HT Receptor
,
Opioid Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
|
Mirtazapine (6-Azamianserin) is a tetracyclic antidepressant with a somewhat unique mechanism of action. Mirtazapine therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and h... |
|
T16759 |
Ritanserin
|
R 55667 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
|
Ritanserin (R 55667) is a highly effective, relatively selective, long-acting antagonist of 5-HT2 receptor (IC50: 0.9 nM), less active on Histamine H1, Dopamine D2, Adrenergic α1, Adrenergic α2 receptors. |
